randomly methylated β-cyclodextrin (mcd Search Results


stm2457  (MedChemExpress)
96
MedChemExpress stm2457
METTL3 inhibitor, <t>STM2457,</t> significantly inhibited HCC cell growth, in vitro and in vivo . A, Huh7 and PLC/PRF/5 cells were treated with METTL3 inhibitor STM2457 at the indicated concentrations for 72 and 96 hours. The cell proliferation was analyzed by WST-1 assay. B, Colony formation analysis of Huh7 and PLC/PRF/5 cells after treatment of METTL3 inhibitor STM2457 at the indicated concentrations for 14 days (left). Quantification of the colony formation assay results are shown in the right. C, Western blot analysis of the protein levels of BMI1, RNF2, and HA2K119ub in Huh7 and PLC/PRF/5 cells after treatment with the METTL3 inhibitor STM2457 (20 µmol/L) for 48 hours. β-Actin was used as loading control. D, Western blot for BMI1 and RNF2 in Huh7 and PLC/PRF/5 cells transfected with BMI1 or RNF2 expression vector. E, WST-1 cell proliferation assay in BMI1 or RNF2 transfected Huh7 and PLC/PRF/5 cells treated with STM2457 (20 µmol/L) for 48h . F, Huh7 cells (1 × 10 6 ) were mixed in Matrigel solution and inoculated directly into the livers of SCID mice ( n = 15). Three weeks after intrahepatic inoculation, the mice were treated with STM2457 (50 mg/kg; n = 6) or vehicle (10% DMSO, 20% captisol in 1× PBS; n = 9) via i.p. injection daily. The mice were sacrificed at 7 weeks after intrahepatic inoculation. Representative gross images of the livers are shown in left. The tumor volumes are shown in right. G, IHC staining of Ki67. The images were analyzed using Motic Digital Slide Assistant. Scale bar, 200 μm. H, The levels of BMI1 and RNF2 proteins in liver tumor tissues from mice treated with vehicle or STM2457 were analyzed by Western blot. β-Actin was used as loading control. Data are expressed as means ± SD. *, P < 0.05; **, P < 0.01; ***, P < 0.001.
Stm2457, supplied by MedChemExpress, used in various techniques. Bioz Stars score: 96/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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stm2457 - by Bioz Stars, 2026-03
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rmβcd  (Cyclolab R D Ltd)
90
Cyclolab R D Ltd rmβcd
METTL3 inhibitor, <t>STM2457,</t> significantly inhibited HCC cell growth, in vitro and in vivo . A, Huh7 and PLC/PRF/5 cells were treated with METTL3 inhibitor STM2457 at the indicated concentrations for 72 and 96 hours. The cell proliferation was analyzed by WST-1 assay. B, Colony formation analysis of Huh7 and PLC/PRF/5 cells after treatment of METTL3 inhibitor STM2457 at the indicated concentrations for 14 days (left). Quantification of the colony formation assay results are shown in the right. C, Western blot analysis of the protein levels of BMI1, RNF2, and HA2K119ub in Huh7 and PLC/PRF/5 cells after treatment with the METTL3 inhibitor STM2457 (20 µmol/L) for 48 hours. β-Actin was used as loading control. D, Western blot for BMI1 and RNF2 in Huh7 and PLC/PRF/5 cells transfected with BMI1 or RNF2 expression vector. E, WST-1 cell proliferation assay in BMI1 or RNF2 transfected Huh7 and PLC/PRF/5 cells treated with STM2457 (20 µmol/L) for 48h . F, Huh7 cells (1 × 10 6 ) were mixed in Matrigel solution and inoculated directly into the livers of SCID mice ( n = 15). Three weeks after intrahepatic inoculation, the mice were treated with STM2457 (50 mg/kg; n = 6) or vehicle (10% DMSO, 20% captisol in 1× PBS; n = 9) via i.p. injection daily. The mice were sacrificed at 7 weeks after intrahepatic inoculation. Representative gross images of the livers are shown in left. The tumor volumes are shown in right. G, IHC staining of Ki67. The images were analyzed using Motic Digital Slide Assistant. Scale bar, 200 μm. H, The levels of BMI1 and RNF2 proteins in liver tumor tissues from mice treated with vehicle or STM2457 were analyzed by Western blot. β-Actin was used as loading control. Data are expressed as means ± SD. *, P < 0.05; **, P < 0.01; ***, P < 0.001.
Rmβcd, supplied by Cyclolab R D Ltd, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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randomly methylated beta-cyclodextrin (rm-β-cd  (Millipore)
90
Millipore randomly methylated beta-cyclodextrin (rm-β-cd
METTL3 inhibitor, <t>STM2457,</t> significantly inhibited HCC cell growth, in vitro and in vivo . A, Huh7 and PLC/PRF/5 cells were treated with METTL3 inhibitor STM2457 at the indicated concentrations for 72 and 96 hours. The cell proliferation was analyzed by WST-1 assay. B, Colony formation analysis of Huh7 and PLC/PRF/5 cells after treatment of METTL3 inhibitor STM2457 at the indicated concentrations for 14 days (left). Quantification of the colony formation assay results are shown in the right. C, Western blot analysis of the protein levels of BMI1, RNF2, and HA2K119ub in Huh7 and PLC/PRF/5 cells after treatment with the METTL3 inhibitor STM2457 (20 µmol/L) for 48 hours. β-Actin was used as loading control. D, Western blot for BMI1 and RNF2 in Huh7 and PLC/PRF/5 cells transfected with BMI1 or RNF2 expression vector. E, WST-1 cell proliferation assay in BMI1 or RNF2 transfected Huh7 and PLC/PRF/5 cells treated with STM2457 (20 µmol/L) for 48h . F, Huh7 cells (1 × 10 6 ) were mixed in Matrigel solution and inoculated directly into the livers of SCID mice ( n = 15). Three weeks after intrahepatic inoculation, the mice were treated with STM2457 (50 mg/kg; n = 6) or vehicle (10% DMSO, 20% captisol in 1× PBS; n = 9) via i.p. injection daily. The mice were sacrificed at 7 weeks after intrahepatic inoculation. Representative gross images of the livers are shown in left. The tumor volumes are shown in right. G, IHC staining of Ki67. The images were analyzed using Motic Digital Slide Assistant. Scale bar, 200 μm. H, The levels of BMI1 and RNF2 proteins in liver tumor tissues from mice treated with vehicle or STM2457 were analyzed by Western blot. β-Actin was used as loading control. Data are expressed as means ± SD. *, P < 0.05; **, P < 0.01; ***, P < 0.001.
Randomly Methylated Beta Cyclodextrin (Rm β Cd, supplied by Millipore, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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randomly methylated beta-cyclodextrin (rm-β-cd - by Bioz Stars, 2026-03
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randomly methylated (1.8) β-cyclodextrin (m-β-cd)  (Wacker Chemie)
90
Wacker Chemie randomly methylated (1.8) β-cyclodextrin (m-β-cd)
METTL3 inhibitor, <t>STM2457,</t> significantly inhibited HCC cell growth, in vitro and in vivo . A, Huh7 and PLC/PRF/5 cells were treated with METTL3 inhibitor STM2457 at the indicated concentrations for 72 and 96 hours. The cell proliferation was analyzed by WST-1 assay. B, Colony formation analysis of Huh7 and PLC/PRF/5 cells after treatment of METTL3 inhibitor STM2457 at the indicated concentrations for 14 days (left). Quantification of the colony formation assay results are shown in the right. C, Western blot analysis of the protein levels of BMI1, RNF2, and HA2K119ub in Huh7 and PLC/PRF/5 cells after treatment with the METTL3 inhibitor STM2457 (20 µmol/L) for 48 hours. β-Actin was used as loading control. D, Western blot for BMI1 and RNF2 in Huh7 and PLC/PRF/5 cells transfected with BMI1 or RNF2 expression vector. E, WST-1 cell proliferation assay in BMI1 or RNF2 transfected Huh7 and PLC/PRF/5 cells treated with STM2457 (20 µmol/L) for 48h . F, Huh7 cells (1 × 10 6 ) were mixed in Matrigel solution and inoculated directly into the livers of SCID mice ( n = 15). Three weeks after intrahepatic inoculation, the mice were treated with STM2457 (50 mg/kg; n = 6) or vehicle (10% DMSO, 20% captisol in 1× PBS; n = 9) via i.p. injection daily. The mice were sacrificed at 7 weeks after intrahepatic inoculation. Representative gross images of the livers are shown in left. The tumor volumes are shown in right. G, IHC staining of Ki67. The images were analyzed using Motic Digital Slide Assistant. Scale bar, 200 μm. H, The levels of BMI1 and RNF2 proteins in liver tumor tissues from mice treated with vehicle or STM2457 were analyzed by Western blot. β-Actin was used as loading control. Data are expressed as means ± SD. *, P < 0.05; **, P < 0.01; ***, P < 0.001.
Randomly Methylated (1.8) β Cyclodextrin (M β Cd), supplied by Wacker Chemie, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/result/randomly methylated (1.8) β-cyclodextrin (m-β-cd)/product/Wacker Chemie
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randomly methylated (1.8) β-cyclodextrin (m-β-cd) - by Bioz Stars, 2026-03
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randomly methylated β-cyclodextrin  (Cyclolab R D Ltd)
90
Cyclolab R D Ltd randomly methylated β-cyclodextrin
Viability (%) of HepG2 cells as a function of flavylium compounds 5 ( A ) and 7 ( B ), and their cyclodextrin complex concentration with SBECD and <t>RAMEB,</t> respectively.
Randomly Methylated β Cyclodextrin, supplied by Cyclolab R D Ltd, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/result/randomly methylated β-cyclodextrin/product/Cyclolab R D Ltd
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randomly methylated β-cyclodextrin - by Bioz Stars, 2026-03
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randomly methylated-\u03b2-cyclodextrin (rameb)  (Cyclolab R D Ltd)
90
Cyclolab R D Ltd randomly methylated-\u03b2-cyclodextrin (rameb)
Viability (%) of HepG2 cells as a function of flavylium compounds 5 ( A ) and 7 ( B ), and their cyclodextrin complex concentration with SBECD and <t>RAMEB,</t> respectively.
Randomly Methylated \U03b2 Cyclodextrin (Rameb), supplied by Cyclolab R D Ltd, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/result/randomly methylated-\u03b2-cyclodextrin (rameb)/product/Cyclolab R D Ltd
Average 90 stars, based on 1 article reviews
randomly methylated-\u03b2-cyclodextrin (rameb) - by Bioz Stars, 2026-03
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methylated β-cyclodextrin cavasol® w7m  (Merck KGaA)
90
Merck KGaA methylated β-cyclodextrin cavasol® w7m
Viability (%) of HepG2 cells as a function of flavylium compounds 5 ( A ) and 7 ( B ), and their cyclodextrin complex concentration with SBECD and <t>RAMEB,</t> respectively.
Methylated β Cyclodextrin Cavasol® W7m, supplied by Merck KGaA, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/result/methylated β-cyclodextrin cavasol® w7m/product/Merck KGaA
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methylated β-cyclodextrin cavasol® w7m - by Bioz Stars, 2026-03
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randomly methylated β-cyclodextrin (rmcd  (Cyclodextrin Technologies Development)
90
Cyclodextrin Technologies Development randomly methylated β-cyclodextrin (rmcd
Viability (%) of HepG2 cells as a function of flavylium compounds 5 ( A ) and 7 ( B ), and their cyclodextrin complex concentration with SBECD and <t>RAMEB,</t> respectively.
Randomly Methylated β Cyclodextrin (Rmcd, supplied by Cyclodextrin Technologies Development, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/result/randomly methylated β-cyclodextrin (rmcd/product/Cyclodextrin Technologies Development
Average 90 stars, based on 1 article reviews
randomly methylated β-cyclodextrin (rmcd - by Bioz Stars, 2026-03
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water soluble cholesterol/rameb complex  (Cyclolab R D Ltd)
90
Cyclolab R D Ltd water soluble cholesterol/rameb complex
Viability (%) of HepG2 cells as a function of flavylium compounds 5 ( A ) and 7 ( B ), and their cyclodextrin complex concentration with SBECD and <t>RAMEB,</t> respectively.
Water Soluble Cholesterol/Rameb Complex, supplied by Cyclolab R D Ltd, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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water soluble cholesterol/rameb complex - by Bioz Stars, 2026-03
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6-monodeoxy-6-monoamino-randomly-methylated-beta-cyclodextrin hydrochloride (nh2-rameb)  (Cyclolab R D Ltd)
90
Cyclolab R D Ltd 6-monodeoxy-6-monoamino-randomly-methylated-beta-cyclodextrin hydrochloride (nh2-rameb)
Viability (%) of HepG2 cells as a function of flavylium compounds 5 ( A ) and 7 ( B ), and their cyclodextrin complex concentration with SBECD and <t>RAMEB,</t> respectively.
6 Monodeoxy 6 Monoamino Randomly Methylated Beta Cyclodextrin Hydrochloride (Nh2 Rameb), supplied by Cyclolab R D Ltd, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/result/6-monodeoxy-6-monoamino-randomly-methylated-beta-cyclodextrin hydrochloride (nh2-rameb)/product/Cyclolab R D Ltd
Average 90 stars, based on 1 article reviews
6-monodeoxy-6-monoamino-randomly-methylated-beta-cyclodextrin hydrochloride (nh2-rameb) - by Bioz Stars, 2026-03
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7% randomly methylated beta cyclodextrin (rmcd) trappsol r©  (CTD Inc)
90
CTD Inc 7% randomly methylated beta cyclodextrin (rmcd) trappsol r©
Viability (%) of HepG2 cells as a function of flavylium compounds 5 ( A ) and 7 ( B ), and their cyclodextrin complex concentration with SBECD and <t>RAMEB,</t> respectively.
7% Randomly Methylated Beta Cyclodextrin (Rmcd) Trappsol R©, supplied by CTD Inc, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/result/7% randomly methylated beta cyclodextrin (rmcd) trappsol r©/product/CTD Inc
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7% randomly methylated beta cyclodextrin (rmcd) trappsol r© - by Bioz Stars, 2026-03
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randomly methylated β-cd  (AOP Orphan Pharmaceuticals AG)
90
AOP Orphan Pharmaceuticals AG randomly methylated β-cd
Viability (%) of HepG2 cells as a function of flavylium compounds 5 ( A ) and 7 ( B ), and their cyclodextrin complex concentration with SBECD and <t>RAMEB,</t> respectively.
Randomly Methylated β Cd, supplied by AOP Orphan Pharmaceuticals AG, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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randomly methylated β-cd - by Bioz Stars, 2026-03
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Image Search Results


METTL3 inhibitor, STM2457, significantly inhibited HCC cell growth, in vitro and in vivo . A, Huh7 and PLC/PRF/5 cells were treated with METTL3 inhibitor STM2457 at the indicated concentrations for 72 and 96 hours. The cell proliferation was analyzed by WST-1 assay. B, Colony formation analysis of Huh7 and PLC/PRF/5 cells after treatment of METTL3 inhibitor STM2457 at the indicated concentrations for 14 days (left). Quantification of the colony formation assay results are shown in the right. C, Western blot analysis of the protein levels of BMI1, RNF2, and HA2K119ub in Huh7 and PLC/PRF/5 cells after treatment with the METTL3 inhibitor STM2457 (20 µmol/L) for 48 hours. β-Actin was used as loading control. D, Western blot for BMI1 and RNF2 in Huh7 and PLC/PRF/5 cells transfected with BMI1 or RNF2 expression vector. E, WST-1 cell proliferation assay in BMI1 or RNF2 transfected Huh7 and PLC/PRF/5 cells treated with STM2457 (20 µmol/L) for 48h . F, Huh7 cells (1 × 10 6 ) were mixed in Matrigel solution and inoculated directly into the livers of SCID mice ( n = 15). Three weeks after intrahepatic inoculation, the mice were treated with STM2457 (50 mg/kg; n = 6) or vehicle (10% DMSO, 20% captisol in 1× PBS; n = 9) via i.p. injection daily. The mice were sacrificed at 7 weeks after intrahepatic inoculation. Representative gross images of the livers are shown in left. The tumor volumes are shown in right. G, IHC staining of Ki67. The images were analyzed using Motic Digital Slide Assistant. Scale bar, 200 μm. H, The levels of BMI1 and RNF2 proteins in liver tumor tissues from mice treated with vehicle or STM2457 were analyzed by Western blot. β-Actin was used as loading control. Data are expressed as means ± SD. *, P < 0.05; **, P < 0.01; ***, P < 0.001.

Journal: Molecular Cancer Research

Article Title: METTL3-Mediated m 6 A Modification Regulates the Polycomb Repressive Complex 1 Components BMI1 and RNF2 in Hepatocellular Carcinoma Cells

doi: 10.1158/1541-7786.MCR-24-0362

Figure Lengend Snippet: METTL3 inhibitor, STM2457, significantly inhibited HCC cell growth, in vitro and in vivo . A, Huh7 and PLC/PRF/5 cells were treated with METTL3 inhibitor STM2457 at the indicated concentrations for 72 and 96 hours. The cell proliferation was analyzed by WST-1 assay. B, Colony formation analysis of Huh7 and PLC/PRF/5 cells after treatment of METTL3 inhibitor STM2457 at the indicated concentrations for 14 days (left). Quantification of the colony formation assay results are shown in the right. C, Western blot analysis of the protein levels of BMI1, RNF2, and HA2K119ub in Huh7 and PLC/PRF/5 cells after treatment with the METTL3 inhibitor STM2457 (20 µmol/L) for 48 hours. β-Actin was used as loading control. D, Western blot for BMI1 and RNF2 in Huh7 and PLC/PRF/5 cells transfected with BMI1 or RNF2 expression vector. E, WST-1 cell proliferation assay in BMI1 or RNF2 transfected Huh7 and PLC/PRF/5 cells treated with STM2457 (20 µmol/L) for 48h . F, Huh7 cells (1 × 10 6 ) were mixed in Matrigel solution and inoculated directly into the livers of SCID mice ( n = 15). Three weeks after intrahepatic inoculation, the mice were treated with STM2457 (50 mg/kg; n = 6) or vehicle (10% DMSO, 20% captisol in 1× PBS; n = 9) via i.p. injection daily. The mice were sacrificed at 7 weeks after intrahepatic inoculation. Representative gross images of the livers are shown in left. The tumor volumes are shown in right. G, IHC staining of Ki67. The images were analyzed using Motic Digital Slide Assistant. Scale bar, 200 μm. H, The levels of BMI1 and RNF2 proteins in liver tumor tissues from mice treated with vehicle or STM2457 were analyzed by Western blot. β-Actin was used as loading control. Data are expressed as means ± SD. *, P < 0.05; **, P < 0.01; ***, P < 0.001.

Article Snippet: Three weeks after intrahepatic inoculation, the mice were randomly divided into two groups and treated with STM2457 (MedChemExpress; 50 mg/kg, 10% DMSO, 20% captisol in 1× PBS; n = 6) or vehicle (10% DMSO, 20% captisol in 1× PBS; n = 9) via i.p. injection daily for 4 weeks.

Techniques: In Vitro, In Vivo, WST-1 Assay, Colony Assay, Western Blot, Control, Transfection, Expressing, Plasmid Preparation, Proliferation Assay, Injection, Immunohistochemistry

Viability (%) of HepG2 cells as a function of flavylium compounds 5 ( A ) and 7 ( B ), and their cyclodextrin complex concentration with SBECD and RAMEB, respectively.

Journal: International Journal of Molecular Sciences

Article Title: Halochromic Behavior and Anticancer Effect of New Synthetic Anthocyanidins Complexed with β-Cyclodextrin Derivatives

doi: 10.3390/ijms23158103

Figure Lengend Snippet: Viability (%) of HepG2 cells as a function of flavylium compounds 5 ( A ) and 7 ( B ), and their cyclodextrin complex concentration with SBECD and RAMEB, respectively.

Article Snippet: Sulfobutylether-β-cyclodextrin (SBECD) and randomly methylated β-cyclodextrin (RAMEB) were a kind gift provided by Cyclolab (Budapest, Hungary).

Techniques: Concentration Assay